Research programmes and networking PDF Print

One of the priorities of FICAM is the participation in national (e.g. TEKES projects) and international (e.g. EU projects) projects in cowork both with scientific and governmental organizations.

ERDF

The European Regional Development Fund (ERDF) financed (2013-2014) project“Development of the Function Model of FICAM “. The project promotes the innovations and networking of FICAM and  strengthens  the structures of expertise.

The Ministry of Agriculture and Forestry financed  3-year (2014-2016) research programme for FICAM: “Development of human-cell-based non animal test methods and information sharing on these methods”. This  programme of the Finnish Ministry of Agriculture and Forestry  is connected to the EU directive 2010/63 on the protection of animals used for scientific purposes.

According to the EU directive (2010/63), the use of experimental animals should be reduced and replaced with non-animal experimentation in research and education as soon as this is scientifically possible.

Ministry of Agriculture and Forestry supports financially the three-year programme of FICAM, which has the goal to develop and promote alternative, human-cell-based research methods to replace and reduce animal experiments.

The main focus of the programme of FICAM is to develop vasculogenesis and heart models which can replace and reduce animal experimentation.

Vasculogenesis model can be developed to be used in reproduction toxicology and mechanistic studies. The need of alternative tests in reproduction toxicology is great because the great number of animals used in these tests at present. The model can also be used when testing the efficacy of pharmaceuticals, e.g. drugs for cancer and eye diseases.

In the heart model the vasculogenesis model and heart cells differentiated from human stem cells are combined to form a functional heart tissue. The developed test is applicable for the efficacy testing of  drugs and for safety evaluation of chemicals.

One part of the programme is the  information sharing about alternative test methods which are in use or under development in FICAM and in other research institutions. FICAM shares information also about alternative non-animal test methods which are in regulatory guidelines and which have passed international validations and are near the acceptance to official regulations.

ISTNET

FICAM is an initiator for a new strategy to speed up development of alternative methods for regulatory purposes. The principle is called ISTNET (International Stakeholder Network). The main focus is on bringing scientists, regulators and industry people together to define test requirements and to adapt test development and standardisation for various toxicological end points. The first ISTNET network created for (developmental) neurotoxicity testing started in the beginning of 2014. FICAM is one of the leading promoters of this network.

PARERE NETWORK

PARERE (Preliminary Assessment of Regulatory Relevance) Network under Article 47(5) of Directive 2010/63/EU evaluates alternative methods to be accepted into regulatory guidelines.

Nominated by the Finnish Ministry of Agriculture and Forestry, Finland’s PARERE person  in this network is Adjunct Professor Tuula Heinonen, Director of FICAM.

 

The Ministry of Agriculture and Forestry financed  3-year (2014-2016) research programme for FICAM: “Development of human-cell-based non animal test methods and information sharing on these methods”. This  programme of the Finnish Ministry of Agriculture and Forestry  is connected to the EU directive 2010/63 on the protection of animals used for scientific purposes. Normal 0 false false false EN-US X-NONE X-NONE